Lymphoma mantle cell

An aggressive, usually diffuse non-Hodgkin lymphoma composed of small to medium sized B-lymphocytes (centrocytes). Most patients present with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The gastrointestinal tract is the most commonly affected extranodal site by this type of non-Hodgkin lymphoma. The vast majority of cases express the t(11;14)(q13;q32) resulting in the rearrangement of the BCL-1 gene and the overexpression of cyclin D1 mRNA.

Disease Alternative Name

classical mantle cell lymphoma
mantle cell lymphoma
mcl
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Pondicherry
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The Gujarat Cancer & Research Institute

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Shri M P Shah Medical College

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Lady Hardinge Medical College

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M.P.SHAH MEDICAL COLLEGE

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